In line with the CiPA initiative,

in silico computational reconstruction of the human cardiac action potential

is one of the three in vitro safety pharmacology methods to be used

in order to reduce drug attrition earlier, faster and cheaper

during the process of drug candidate discovery



Safe Cardiac Action Potential Test (SCAP Test)

is a database describing

the effects of various ions, cardiac currents or drugs

on human epi-, mid and endocardial myocytes cardiac action potential

studied by in silico computational simulation using the O'Hara Rudy model