Cardiac action potential simulation

 

 

 scaptes

 

In line with the CiPA initiative, 

this site helps you to determine

the cardiac risks of drugs

using in silico cardiac action potential simulation

based on search for:

 

Early afterdepolarization facilitation (EAD)

Transmural dispersion of repolarization (TDR)

Reverse use dependence (RUD)

Triangulation

Action potential duration (APD) : prolongation or shortening

Maximal rate of AP rise: Vmax increase or decrease

qnet (integration sum of ICaL+IKr+IKs+INaL+Ito+IK1)

Vmin (minimal rate of AP decrease at the EAD take-off voltage)

 

 

At the time being, 151 drugs are described regarding their in silico cardiac safety profile (please sign in in order to see the safety profile):

Ajmaline, Alfuzosin, Almokalant, Alvimopan, Ambrisentan, Amiodarone, Amitriptyline, Amlodipine, Aspirin, Astemizole, Atenolol, Azimilide, Azithromycin, Bepridil, Ceftriaxone, Cetirizine, Chloroquine, Chlorpheniramine, Chlorpromazine, Cibenzoline, Cilostazol, Ciprofloxacin, Cisapride, Citalopram, Clarithromycin, Clozapine, Darifenacin, Darunavir, Dasatinib, Deferasirox, Desipramine, Desvenlafaxine, Diazepam, Diltiazem, Diphenhydramine, Disopyramide, Dobutamine, Dofetilide, Dolasetron, Domperidone, Donepezil, Doripenem, Doxorubicin, Dronedarone, Droperidol, Duloxetine, E-4031, Ebastine, Eltrombopag, Encainide, Erythromycin, Etravirine, Everolimus, Famotidine, Fexofenadine, Flecainide, Fluoxetine, Fluvoxamine, Galantamine, Gatifloxacin, Gefitinib, Halofantrine, Haloperidol, Hydroxychloroquine, Hydroxyzine, Ibutilide, Imipramine, Ivabradine, Ketanserin, Ketoconazole, Lacosamide, Lamivudine, Lamotrigine, Lapatinib, Levocetirizine, Levofloxacin,  Levosimendan, Lidocaine, Linezolid, Lopinavir, Loratadine, Maraviroc, Mefloquine, Methadone, Metoprolol, Metronidazole, Mexiletine, Mibefradil, Milrinone, Mitoxantrone, Moxifloxacin, Nebivolol, Nelfinavir, Nicardipine, Nifedipine, Nilotinib, Nimodipine, Nisoldipine, Nitrendipine, Ofloxacin, Olanzapine, Omecamtiv mecarbil, Ondansetron, Oxybutinin, Paliperidone, Palonosetron, Paroxetine, Pentamidine, Pentobarbital, Phenytoin, Pimozide, Piperacillin, Prenylamine,  Primidone, Procainamide, Propafenone, Propranolol, Quetiapine, Quinidine, Quinine, Raltegravir, Ranolazine, Ribavirin, Risperidone, Ritonavir, Rufinamide, Saquinavir, Sertindole, Sertraline, Sildenafil, Silodosin, Sitaglitin, Solifenacin, Sotalol, Sparfloxacin, Sunitinib, Tadalafil, Tamoxifen, Tedisamil, Telbivudine, Terfenadine, Terodiline, Thioridazine, Tolterodine, Vandetanib, Vanoxerine, Vardenafil, Verapamil, Vernakalant, Voriconazole, Ziprasidone